The great trailblazer and hero Daniel Boone is portrayed as the true American legend that he is in this adventurous film. In the year 1774 Daniel Boone (George O'Brien) leads thirty settler families from North Carolina to Kentucky where they face two opposing threats. White man Simon Girty (John Carradine) leads Indian raiders who opposes settlement, and Stephen Marlowe (Ralph Forbes) seeks to seize title to the new lands.